Adolescent footballers exhibit smaller change of direction (COD) deficits than adults, suggesting distinct biomechanical profiles; however, the role of physical performance variables in COD, considering maturation and injury-related factors, remains poorly understood. This study aimed to examine the relationships between sprint, jump, and COD performance, maturation status, and injury-related variables in young male footballers. Fifty-six national-level players (age: 16.67 ± 0.86 years) performed unilateral vertical and horizontal jump tests, 20 m linear sprint tests, and 180° COD assessments. Maturation status was estimated using peak height velocity (PHV), and injury incidence and severity were recorded over one competitive season. Associations were observed between PHV and sprint performance during the initial acceleration phase (0-10 m; p < 0.01). Unilateral jump measures were associated with sprint and COD performance, whereas inter-limb asymmetries showed limited associations with performance outcomes. Horizontal jump performance was also associated with the percentage-based COD deficit (%CODD). With respect to injury-related variables, injury incidence was associated with countermovement jump (CMJ) measures, with greater CMJ asymmetry being associated with higher injury incidence, while both unilateral CMJ variables were retained in the regression model. Overall, these findings suggest that biological maturation and unilateral neuromuscular performance may be relevant factors associated with youth football performance, whereas inter-limb asymmetry appears to play a more limited role; CMJ-related measures may warrant further consideration in relation to injury incidence in adolescent footballers.
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